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Caspase-8 (Active) Antibody
Catalog#: 3259-100 | Size: 100 µg
Antibody Target: Caspase-8 (Active) Alternative Name: CASP8 , MGC78473 , CASP-8, MACH, procaspase-8, MCH5, ALPS2B, FLICE, CAP4, EC 3.4.22.61 Host: Rabbit Antibody Type: Polyclonal Isotype: Rabbit IgG Immunogen: Synthetic peptide corresponding to residues surrounding amino acid 392 of mouse caspase-8 Accession#: BC006737 Gene ID: 12370 Appearance: Colorless liquid Concentration: 0.5 mg/ml Formulation: 100 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in PBS containing 50% glycerol, 0.5% BSA, and 0.01% thimerosal. Purification: Affinity purified Species Reactivity: mouse, rat Application: Western blot Application & Usage: Western blotting (0.5-4 µg/ml) in samples from mouse and rat origins. However, the optimal conditions should be determined individually. The antibody detects the 25 kDa large subunit of caspase-8. It does not detect the full-length of caspase-8. Storage Temp.: -20 °C Shipping: gel pack Background Descriptions: Caspase-8, a member of the caspase-family of proteases, plays a key role in mediating Fas (CD95) and TNF induced apoptosis. Caspase-8 is synthesized as inactive pro-enzyme and activation of the enzyme involves proteolytic cleavage that leads to the release of the active p18 and p10 subunits. Activated caspase-8 is able to cleave and activate downstream caspases, such as caspase-3, -6, -7 and a death agonist member of the Bcl-2/Bcl-xL family, Bid, leading to apoptosis. Handling: The antibody solution should be gently mixed before use. Usage: For Research Use Only! Not to be used in humans.
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